Publications
Molecular Therapy
2025
Neonatal systemic gene therapy restores cardiorespiratory function in a rat model of Pompe disease
Biochemical assays showed that AAV treatment increased GAA activity in the heart, diaphragm, quadriceps and spinal cord.
Fuller, D.D., Rana, S., Thakre, P., Benevides, E., Pope, M., Todd, A.G., Jensen, V.N., Vaught, L., Cloutier, D., Ribas, R.A., Larson, R.C., Gentry, M.S., Sun, R.C., Chandran, V., Corti, M., Falk, D.J., Byrne, B.J.
Nature Metabolism
2025
Glycogen Drives Tumor Initiation and Progression in Lung Adenocarcinoma
Our findings support the conclusion that glycogen accumulation drives LUAD cancer progression and provide a framework for integrating spatial metabolomics with translational models to uncover metabolic drivers of cancer.
Clarke, H. A., Hawkinson, T. R., Shedlock, C. J., Medina, T., Ribas, R. A., Wu, L., Liu, Z., Ma, X., Xia, Y., Huang, Y., He, X., Chang, J. E., Young, L. E. A., Juras, J. A., Buoncristiani, M. D., James, A. N., Rushin, A., Merritt, M. E., Mestas, A., Lamb, J. F., Manauis, E. C., Austin, G. L., Chen, L., Singh, P. K., Bian, J., Vander Kooi, C. W., Evers, M. B., Brainson, C. F., Allison, D. B., Gentry, M. S., Sun, R. C.
STAR Protocols
2025
Protocol for high-power, brain-focused microwave fixation to define rodent metabolism
Analysis of metabolites provides key insights into brain physiology and function. Due to post-mortem metabolism, both the euthanasia method and dissection time can make a critical difference. Here, we describe a protocol to euthanize rodents by microwave irradiation. This workflow details steps for animal placement, tissue fixation, and post-fixation processing.
Cantrell, A.R., Hawkinson, T.R., Juras, J.A., Webb, M.B., Medina, T., Ribas, R.A., Collins, J., Bunnell, A.A., Young, L.E.A., Markussen, K.H., Anrdes, D.A., Long, J.R., Vander Kooi, C., Smith, B.N., Sun, R.C., and Gentry, M.S.
Journal of Medicinal Chemistry
2025
Discovery and Evaluation of Active Site-Directed, Potent, and Selective Sulfophenyl Acetic Amide-Based Inhibitors for the Laforin Phosphatase
Here, we identified sulfophenyl acetic amide (SPAA), as a novel nonhydrolyzable phosphotyrosine mimetic for laforin inhibition.
Lin, J., R. He, Z. Qu, J. Dong, A. D. Krabill, L. Wu, Y. Bai, L. R. Conroy, R. C. Bruntz, Y. Miao, B. A. Jassim, B. Babalola, F. G. B. Nguele Meke, Sun, RC., M. S. Gentry and Z.-Y. Zhang
Nature Communications
2025
Spatial Mapping of the Brain Metabolome Lipidome and Glycome
Metabolites, lipids, and glycans are fundamental but interconnected classes of biomolecules that form the basis of the metabolic network. These molecules are dynamically channeled through multiple pathways that govern cellular physiology and pathology. Here, we present a framework for the simultaneous spatial analysis of the metabolome, lipidome, and glycome from a single tissue section using mass spectrometry imaging.
Clarke, H. A., Ma, X., shedlock, c. J., medina, t., Hawkinson, T. R., Wu, L., Robas, R. A., Ravi, S., Bizon, J. L., Burke, S. N., Gentry, M.S., and Sun, R.C
Obesity
2025
A real-world cohort study of immune-related adverse events in patients receiving immune checkpoint inhibitors
This study aimed to identify and evaluate risk factors for immune-related adverse events (irAEs) among patients receiving ICIs, focusing on patient demographics, comorbidities, cancer types, and ICI regimens. Additionally, we sought to examine the incidence, severity, and organ-specific patterns of irAEs to guide personalized management strategies.
Wang Y, Guo Y, Tan AC, Zhao L, Shi X, Chen Y, Sun RC, Liu M, Su J, George TJ, Bian J.
Nature Metabolism
2025
AI-driven Framework to Map the Brain Metabolome in 3D
Our framework uses advanced algorithms for image registration, normalization and interpolation to enable the integration of serial 2D tissue sections, thereby generating a comprehensive 3D model of unique diverse metabolites across host tissues at submesoscale.
Ma, X., Shedlock, C. J., Medina, T., Ribas, R. A., Clarke, H. A., Hawkinson, T. R., Dande, P. K., Wu, L., Ziani, B. E. C., Burke, S. N., Merritt, M. E., Vander Kooi, C. W., Gentry, M. S., Yadav, N. N., Chen, L., Sun, R. C.
JAMA Oncology
2025
Association of GLP-1 Receptor Agonists with Cancer Risk in Obese Adults: A Target Trial Emulation
Dai, H., Li, Y., Sun, R. C., George, T. J., Nakshatri, H., Lee, K. P., Guo, S. J., Allen, J. M., Donahoo, W. T., Guo, Y., Lee, Y. A.
Molecular Cancer Research
2025
GDP-mannose 4, 6-Dehydratase is a Key Driver of MYCN-amplified Neuroblastoma Core Fucosylation and Tumorigenesis
High GMDS expression was found to be associated with poor patient survival, advanced stage disease, and MYCN-amplification in human NB tumors.
Rellinger, E., Zhu, B., Pitts, M., Buoncristiani, M., Bryant, L., Gurria, J., Sun, R.C
Translational Research
2025
Predictive Modeling of ARDS Mortality Integrating Biomarker/Cytokine, Clinical and Metabolomic Data
Together, these findings demonstrate the promise of integrating multimodal data to improve ARDS prognostication and to provide important insights into the complex metabolic derangements underlying severe ARDS.
Rafikov, Ruslan, Debrah M. Thompson, Olga Rafikova, Sara M. Camp, Roberto A. Ribas,. Sun RC, Matthew S. Gentry, Nancy G. Casanova, and Joe GN Garcia.
