Publications
JCI Insight
2024
GalNAc-siRNA Mediated Knockdown of Ketohexokinase Versus Systemic, Small Molecule Inhibition of its Kinase Activity Exert Divergent Effects on Hepatic Metabolism in Mice on a HFD
Park, S.-H., Fadhul, T., Conroy, L. R., Clarke, H., Sun, R. C., Wallenius, K., Boucher, J., O'Mahony, G., Boianelli, A., Persson, M., Noetzli, L., Tu, H.-C., Fitzgerald, K., Martinez, G. J., Terry D. Hinds, J., Divanovic, S., and Softic, S.
bioRxiv
2024
Cortical inhibitory parvalbumin interneurons exhibit metabolic specializations coordinated by PGC-1α that are lost in rodents and humans after traumatic brain injury
Quiñones, S., Wang, J. C., Kim, E., Bottom-Tanzer, S., Armbruster, M., Macêdo, J. K., Sun, R.C & Dulla, C. G.
bioRxiv
2024
TgLaforin, a glucan phosphatase, reveals the dynamic role of storage polysaccharides in Toxoplasma gondii tachyzoites and bradyzoites
Murphy, R. D., Troublefield, C. A., Miracle, J. S., Young, L. E., Tripathi, A., Brizzee, C. O., ... & Sinai, A. P.
Under Review in Cancer Cell
2024
Causal Multi-omics Integration Reveals Lipid Storage Dependency in Lethal Group 3 Medulloblastoma
Bernardi, F.; Torrejon, J. D.; Basili, I.; Van Ommeren, R, Sun, R. C; Beccaria, K.; Dufour, C.; Sarry, J.-E.; Michealraj, A.; Taylor, M. D.; Ayrault, O.
bioRxiv
2024
Neonatal systemic gene therapy restores cardiorespiratory function in a rat model of Pompe disease
Fuller, D., Rana, S., Thakre, P., Benevides, E. S., Pope, M., Sun, RC, Todd, A. G., ... & Byrne, B. J.
Science Translational Medicine
2024
Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders
Ullman, J.C., Mellem, K.T., Xi, Y., Ramanan, V., Merritt, H., Choy, R., Gujral, T., Young, L.E., Sun R.C.,Blake, K., Tep, S. and Homburger, J.R.
Neurotherapeutics
2024
Neurological glycogen storage diseases and emerging therapeutics
Herein, we provide an overview of current perspectives on n-GSDs, emphasizing recent advances in understanding their molecular basis, therapeutic developments, underscore key challenges and the need to deepen our understanding of n-GSDs pathogenesis to develop better therapeutic strategies that could offer improved treatment and sustainable benefits to the patients.
Colpaert, M., P. K. Singh, K. J. Donohue, N. T. Pires, D. D. Fuller, M. Corti, B. J. Byrne, R. C. Sun, C. W. Vander Kooi and M. S. Gentry
Neuropsychopharmacology
2024
Voltage-gated Potassium Channels in Astrocytes Control Extended Access Cocaine Seeking
Xia, M., Anderson, T., Prantzalos, E., Hawkinson, T., Clarke, H., Keohane, S., Sun, R.C., Turner, J., and Ortinski, P.
Journal of Neuroscience
2024
Imbalance in glucose metabolism regulates the transition of microglia from homeostasis to Disease Associated Microglia stage 1
Liu Y, Kwok W, Yoon H, Ryu JC, Stevens P, Hawkinson TR, Shedlock CJ, Ribas RA, Medina T, Keohane SB, Scharre D, Sun R.C, Yoon S.O.